The Global Tangential Flow Filtration Market size is expected to reach $3.5 billion by 2028, rising at a market growth of 10.9% CAGR during the forecast period
Tangential Flow Filtration (TFF) is a rapid method for purification and separation of elements such as biomolecules. The technique is very versatile and is used in various fields such as immunology, molecular biology, protein chemistry, microbiology and biochemistry.
NEW YORK, December 20, 2022 (GLOBE NEWSWIRE) — Reportlinker.com announces the release of the report, Global Tangential Flow Filtration Market Size, Share & Industry Trends Analysis Report By Technology, By Product, By Application, By End-User , by Regional Outlook and Forecast, 2022-2028″ – https://www.reportlinker.com/p06374172/?utm_source=GNW
The process can separate and clean feeds from small volumes, such as 10mL, to large volumes, ranging from around a thousand liters.
TFF can be efficiently used to harvest cell suspensions, clarify cell lysates and fermentation broths, and fractionate small biomolecules from large ones. In the process, the desired biomolecule or product can be separated from larger molecular weight particles and contaminants, retained, purified, and routed. For the efficient functioning of the process, more emphasis is placed on selecting the right membrane.
Based on the size of the product to be retained, the appropriate membrane would be one that has a molecular weight cutoff (MWCO) that is six times smaller than the product size. The suitability of the membrane MWCO also depends on factors such as processing time considerations, recovery rate, and solute retention and selectivity. In addition, the retention and selectivity of the solute also depend on the molecular structure or shape, the presence of another solute, ionic conditions, the concentration of the solute, and the transmembrane pressure.
In general, the transmembrane pressure is the factor that is considered to be very important for the performance of the TFF itself. The transmembrane pressure is the pressure difference on the two sides of the membrane. Various factors such as permeate viscosity can cause a change in transmembrane pressure. Since permeate viscosity and transmembrane pressure are inversely proportional, increasing the former decreases the latter. This would thereby reduce the overall efficiency of the process.
COVID-19 Impact Analysis
The tangential flow filtration method has been widely used during the pandemic due to the surge in testing and production of viral vectors and vaccines, mainly to find a cure for SARS-CoV-2 prevention. In addition, the increase in manufacturing of COVID-19 vaccines also contributed to the use of TFF in downstream processes such as separation and filtration. The positive results of using TFF during the pandemic further helped the market by attracting more investors and market participants. Several supportive government programs also helped expand facilities, which accelerated the scope of studies being conducted on the use of TFF. Therefore, it can be concluded that the pandemic has had a positive impact on the tangential flow filtration market.
market growth factors
Providing additional benefits compared to standard or normal flow (Nff) filtration
Some key benefits offered by tangential flow filtration are higher flow rates, increased productivity and reduced filter cake formation, which have increased the use of TFF in various industries. TFF, used as a disposable method, also helps reduce cross-contamination of the final product with any retentate. This approach has resulted in an improved version of current TFF technology known as single-pass TFF.
Increasing need for protein separation to produce recombinant proteins
Numerous scientific disciplines including protein chemistry, immunology, molecular DNA/RNA/oligonucleotides, biochemistry and microbiology have used tangential flow filtration techniques. The main uses of TFF in these industries are fractionation of diluted protein mixtures, desalting and concentration of peptides and proteins, and recovery and purification of recombinant proteins or antibodies from cell culture media. TFF’s ability to perform highly efficient diafiltration and concentration processes enables precise separation of intact biomolecules.
Market Inhibiting Factors
High initial flux for microfiltration membranes
A major disadvantage of tangential flow filtration systems is the high initial flow. This is particularly pronounced with TFF microfiltration membranes. The initial flow impedes the carrying volume of subsequent flows and can quickly foul the membrane. As a result, control of transmembrane pressure becomes very prominent, which is only sometimes possible. The high initial flow also reduces the overall flow rate.
Based on the product, the Tangential Flow Filtration market is categorized into Disposable Tangential Flow Filtration Systems, Reusable Tangential Flow Filtration Systems, Membrane Filters, and Filtration Accessories. The disposable TFF systems achieved significant growth rate in tangential flow filtration market in 2021. The disposable TFF systems are preferred and used by several companies, contract manufacturing organizations and contract research organizations. These are also used in research and teaching. This system offers advantages such as smaller footprint, reduced cross-contamination and significantly reduced processing time for the entire batch.
Based on technology, tangential flow filtration market is segmented into ultrafiltration, microfiltration, nanofiltration, and others. The microfiltration segment achieved the largest revenue share in the tangential flow filtration market in 2021. The pore size of these membranes is between 0.1 and 10 microns and they are used extensively in protein fractionation, pretreatment of other membranes and microbial removal. The increased use of microfiltration processes in cell separation processes is the main driver for growth in this segment.
According to application, the tangential flow filtration market is segmented into protein purification, vaccines and viral vectors, antibody purification, raw material filtration and others. The protein purification segment acquired the highest revenue share in the tangential flow filtration market in 2021. The growth of the segment is due to the increasing demand and use of recombinant protein. TFF is used to concentrate and desalt peptides and proteins to recover and purify antibodies.
End User Outlook
Based on end-user, the tangential flow filtration market is segmented into pharmaceutical and biotechnology companies, contract research organizations and contract manufacturing organizations, and academic institutes and research laboratories. Contract Research Organizations (CROs) and Contract Manufacturing Organizations (CMOs) segments achieved significant growth rate in tangential flow filtration market in 2021. Increased demand for biopharmaceuticals, increasing adoption of single-use TFF technologies and growing investments are driving the growth of the segment.
On the basis of region, the tangential flow filtration market is analyzed in North America, Europe, Asia Pacific and LAMEA. The North America segment recorded the largest revenue share in the tangential flow filtration market in 2021. The government in the region has initiated various initiatives and programs that support the widespread use of TFF technology. The increase in research and manufacturing capabilities of biopharmaceutical and pharmaceutical companies continues to drive applications of TFF.
The market research report includes the analysis of the major market players. Major companies featured in the report include Parker Hannifin Corporation, Danaher Corporation, Sartorius Stedim Biotech SA (Sartorius AG), Merck Millipore (Merck Group), Alfa Laval AB, Repligen Corporation, Meissner Filtration Products, Inc., ABEC, Inc., Sterlitech Corporation and Synder Inc.
scope of the study
Market Segments Covered in the Report:
• Nanofiltration and others
• Membrane filter
o Polyethersulfone (PES)
o Polyvinylidene difluoride (PVDF)
o Polytetrafluoroethylene (PTFE)
o Mixed cellulose ester and cellulose acetate
o Polycarbonate Tracked Etched (PCTE)
o Regenerated cellulose and others
• Filtration accessories
• Protein purification
• Antibody purification
• Vaccine and virus vectors
• Raw material filtration
By end users
• Pharmaceutical and biotechnology companies
• CROs and CMOs
• Academic and research institutes
According to geography
• North America
o Rest of North America
o Great Britain
o Rest of Europe
• Asia Pacific
Oh South Korea
o Rest of Asia Pacific
o United Arab Emirates
o Saudi Arabia
o South Africa
o Rest of LAMEA
• Parker Hannifin Corporation
• Danaher Corporation
• Sartorius Stedim Biotech SA (Sartorius AG)
• Merck Millipore (Merck Group)
• Alfa Laval AB
• Replica Corporation
• Meissner Filtration Products, Inc.
• ABEC, Inc.
• Sterlitech Corporation
• Synder Inc.
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